In this section we offer a basic view into topics such as genes which promote longevity such as Sirtuins, pathways that are correlated with metabolic disease such as MThor, detoxification processes & pathways such as NRF2, Ampk and Autophagy. These are Biological systems which are very specific to health and longevity and are becoming more understood in terms of their role in longevity and their relationship with the foods we eat and the activities we engage in such as cold exposure, sauna, fasting, calorie restriction, exercise and sleep.